The Senior Manager of Clinical Data Management (CDM) is a senior leader within Paradigm’s data organization, responsible for overseeing the execution, quality, and operational excellence of data management activities across Phase IV, post-marketing, and real-world evidence (RWE) studies. Reporting to the Head of Clinical Data Management, this leader plays a key role in shaping data delivery strategy, driving cross-functional collaboration, and ensuring consistent, high-quality outcomes across a growing portfolio.

This position requires strong technical expertise, exceptional leadership capability, and the ability to operate strategically while maintaining hands-on oversight of complex data workflows.

What You'll Do:

Leadership & Team Development:

• Lead, mentor, and develop a high-performing team of Clinical Data Managers and CDM operations staff.
• Oversee workload allocation, staffing plans, competency development, and performance management.
• Foster a culture of excellence, continuous improvement, and accountability within the CDM function.

Portfolio Oversight & Data Delivery Excellence:

• Provide senior oversight of end-to-end CDM activities across multiple studies, including database development, CRF design, edit check specification, cleaning and reconciliation workflows, and database lock.
• Ensure predictable delivery of data management milestones through proactive oversight of timelines, metrics, and quality indicators.
• Anticipate operational risks and lead resolution efforts in collaboration with cross-functional partners.

Cross-Functional Partnership:

• Collaborate closely with Clinical Operations, Biostatistics, Safety, Regulatory, Quality, Product, and Engineering to ensure integrated and efficient data delivery.
• Serve as a senior CDM representative in cross-functional study meetings, troubleshooting sessions, and strategic planning discussions.
• Align CDM workflows with broader study goals and portfolio-level priorities.

Process Improvement & Operational Innovation:

• Lead the development, refinement, and adoption of CDM SOPs, templates, libraries, and operational playbooks.
• Drive initiatives to streamline workflows, strengthen data quality controls, and enhance scalability across the CDM organization.
• Support digital transformation initiatives, including automation, modern EDC capabilities, and advanced data review tools.

Sponsor Engagement & Delivery Management:

• Serve as a senior CDM point of contact for sponsors, ensuring transparent communication, timely delivery, and trusted partnership.
• Provide proactive updates, risk assessments, and strategic recommendations to internal and sponsor stakeholders.
• Contribute to proposal development, data strategy discussions, and operational feasibility assessments for new and ongoing programs.

Who You Are:

• 8–12 years of clinical data management experience, with substantial experience leading complex studies or multi-study portfolios.
• Proven leadership experience managing data teams and driving high-quality delivery in fast-paced environments.
• Deep expertise in EDC systems, CDISC standards, data cleaning and reconciliation processes, and regulatory requirements (ICH-GCP, 21 CFR Part 11, GDPR).
• Strong communication skills with the ability to influence, collaborate, and lead across diverse technical and operational teams.
• Highly organized, analytical, and committed to data integrity, operational excellence, and continuous improvement.
• Able to operate strategically while remaining hands-on with complex problem-solving when needed.