The Position

We are seeking a Senior Director, Talent Acquisition & HRBP to lead hiring strategy and execution as the company advances its lead program into late‑stage development and prepares for continued organizational growth. This role is critical to ensure we attract, assess, and hire the talent required to deliver on our clinical and corporate priorities, while also serving as a strategic people partner to the business.

The Senior Director will work closely with executive leadership, functional leaders, and the broader People team to build scalable, high‑quality hiring capabilities. Depending on the experience, interest, and capabilities of the individual hired, this role will also include Human Resources Business Partner (HRBP) responsibilities for select functions.

The Impact You’ll Have

Talent Acquisition Strategy

• Own and execute a company‑wide talent acquisition strategy aligned with late‑stage development milestones and growth plans.
• Lead, coach, and develop the Talent Acquisition team, including recruiters, coordinators, and other recruiting resources as the organization scales.
• Translate business priorities and program timelines into hiring plans and recruiting strategies.
• Build proactive pipelines across core biotech talent markets and manage search firms, contractors, and recruiting vendors.
• Advise leaders on hiring sequencing, role scoping, and talent tradeoffs as the organization scales.

Hiring Execution & Process Excellence

• Partner with functional leaders to recruit for critical clinical, scientific, technical, and operational roles.
• Ensure hiring processes are efficient, rigorous, inclusive, and appropriate for a late‑stage biotech environment.
• Oversee and manage relationships with external search partners.
• Continuously refine Talent Acquisition strategy and practices to ensure a strong candidate experience and high‑quality outcomes.

Workforce Planning & Organizational Scaling

• Collaborate with leadership and translate company milestones, portfolio priorities, and organizational plans into hiring roadmaps, tied to organizational needs.
• Provide input into org design discussions related to growth, team structure, and build‑vs‑buy decisions.
• Use market data and benchmarks to inform hiring and resourcing decisions.

HR Business Partner Responsibilities

• Serve as an HR Business Partner to designated functions, providing strategic people guidance and support.
• Partner with leaders on organizational design, role clarity, team effectiveness, performance management and change management.
• Act as a trusted advisor to leaders navigating growth, complexity, and evolving organizational needs.

As a Senior Director, we also expect you to demonstrate the following Leadership Competencies:

Leadership Competencies

• Communication and Influence
  • Role models clear communication and open two-way conversations.
  • Reinforces an environment where people feel heard and their opinions are valued.
  • Inspires followership despite differing initial opinions.
• Teamwork and Collaboration
  • Champions collaborations and connections across Maze.
  • Establishes team norms and expectations.
  • Seeks opportunities to spotlight team and individual contributions in public forums.
• Execution and Results
  • Develops recommendations to seize on opportunities and mitigate obstacles that could impact long-term success.
  • Coaches others on resource management and work distribution/delegation.
  • Aligns work to Maze’s strategy, mission, and vision.
• Develop Others and Self
  • Develops staff capabilities to handle delegation of responsibilities.
  • Encourages staff to develop and execute personal stretch goals.
  • Identifies and recommends ways to increase inclusive leadership.

What We’re Looking For

• Degree and experience 12+ years of progressive experience in Talent Acquisition and HR leadership roles ideally within biotechnology, life sciences, or other high‑growth environments. (Prefer demonstrated success in building and scaling talent acquisition function in late-stage clinical organization)
• 5+ years of people management experience leading teams in a biotech, biopharma, or similarly complex growth-stage environment
• Experience hiring across clinical development, technical operations, scientific, regulatory, quality, and corporate functions
• Strong judgement as it relates to hiring prioritization, and organizational tradeoffs decisions
• Ability to influence senior leaders and operate effectively in a dynamic environment
• Experience serving as an HR Business Partner or comfort operating in a hybrid TA/HRBP role

This role follows an onsite schedule, with an expectation to be onsite at our South San Francisco headquarters at least five days per week.

About Maze Therapeutics

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. The company is advancing a pipeline using its Compass platform, which allows it to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process it refers to as variant functionalization. The company’s pipeline is led by two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision medicine-based approach for chronic kidney disease. Maze is based in South San Francisco.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.

Stand True – Our integrity is foundational; it guides us no matter the obstacle.

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The expected annual salary range for employees located in the San Francisco Bay Area is $270,000 - $330,000. Additionally, this position is eligible for an annual performance bonus.

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.

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