The Position

We’re looking for a passionate scientist with experience in synthetic organic chemistry to join our collaborative drug discovery team. In this lab-based role, you’ll design and synthesize novel molecules that could transform patient care. You’ll work closely with colleagues across disciplines to optimize compounds for potency, selectivity, and pharmacokinetics, and contribute to advancing innovative drug discovery programs.

The Impact You’ll Have

• Design and synthesize novel chemical entities aligned with project goals.
• Conduct multistep syntheses of complex small molecules and characterize intermediates and final products.
• Collaborate with chemists, biologists, and external partners to optimize pharmacological properties.
• Contribute to patents, reports, and scientific publications.
• Present project results and strategy in key company meetings.
• Mentor junior colleagues and troubleshoot synthetic challenges using literature and best practices.

What We’re Looking For

• Ph.D. in synthetic organic chemistry or related discipline, or M.S. with 5+ years industry experience, or B.S. with 10+ years industry experience.
• Proven expertise in chemical synthesis (publications or industry achievements).
• Strong collaboration skills and a proactive, solution-oriented approach.
• Familiarity with medicinal chemistry concepts and ability to learn quickly.
• Enthusiasm for applying chemistry to solve complex challenges at the intersection of genetics, functional genomics, and biology.
• Excellent communication skills and attention to detail.

About Maze Therapeutics

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. The company is advancing a pipeline using its Compass platform, which allows it to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process it refers to as variant functionalization. The company’s pipeline is led by two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision medicine-based approach for chronic kidney disease. Maze is based in South San Francisco.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.

Stand True – Our integrity is foundational; it guides us no matter the obstacle.

The expected annual salary range for employees located in the San Francisco Bay Area is $134,000 - $163,000. Additionally, this position is eligible for an annual performance bonus.

Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.

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