The Position

The Maze Clinical Sciences team is looking for a Senior Medical Director to play a central role in advancing our clinical development programs. We're looking for passionate and strategic leader to join our team of creative and dedicated professionals on a mission to turn groundbreaking genetic discoveries into life-saving medicines.

As a Senior Medical Director, you will drive the clinical strategy and execution for our pipeline, with specific leadership of our small molecule program targeting APOL1, a key genetic driver of chronic kidney disease. You’ll also contribute to the development of our broader pipeline, which includes precision medicines for renal, cardiac, and metabolic diseases, such as our second novel therapy for chronic kidney disease and phenylketonuria.

Success in this role requires collaboration, scientific curiosity, and leadership. You will work cross-functionally to design, conduct, and analyze key clinical studies, including first-in-human and proof-of-concept trials, helping to shape the future of Maze’s clinical programs. Your impact will be highly visible and integral to our mission.

This position reports to the Head of Clinical Sciences.

The Impact You’ll Have

• Lead the design, execution, and analysis of clinical trials for the APOL1 program.
• Lead the design and execution of clinical development plans for other early-stage clinical assets.
• Author and review clinical-regulatory documents, including study protocols, amendments, informed consents, study reports, and statistical analysis plans (SAPs).
• Develop and deliver scientific presentations and other communication materials for internal and external stakeholders, including investigators, partners, and advocacy groups.
• Engage with scientific thought leaders and patient advocacy groups to gather insights, shape clinical development plans, and build awareness of Maze’s pipeline.
• Partner with Development Science (clinical operations) to select study investigators and sites, ensuring strong professional relationships and engagement.
• Collaborate on the identification, selection, and oversight of vendors and CROs to support clinical program needs.
• Integrate timelines and budgets for clinical activities, aligning with overall corporate objectives in partnership with project management, regulatory, and other key stakeholders.

As a Senior Director, we also expect you to demonstrate the following Leadership Competencies:

• Communication and Influence
  • Builds communication channels across Maze for sharing information
  • Influences Senior Management decisions through persuasive arguments
  • Respectfully addresses differing opinions leading to support of decision
• Teamwork and Collaboration
  • Champions partnerships and connections across Maze
  • Proactively addresses issues that could result in breakdown of team relationships
  • Spotlights team and individual contributions in public forums
• Execution and Results
  • Addresses gaps and leverages strengths to get best results
  • Maintains a steadying presence and clarifies priorities during change
  • Anticipates and removes barriers that put functional/corporate goals at risk
• Develop Others and Self
  • Removes barriers to staff development and empowers them to make their own decisions
  • Stays current on industry trends and keeps direct-reports prepared and responsive

What We’re Looking For

• MD (or equivalent) or MD/PhD with 6+ years of industry experience drug development.
• Board eligibility/certification and clinical experience in internal medicine, pediatrics or surgery (nephrology or cardiometabolic disease expertise preferred).
• Experience as a clinical study medical monitor
• Strong background in developing and reviewing scientific publications, study protocols, investigator brochures, and other clinical-regulatory documents.
• Proven experience in early-stage and/or registration-enabling clinical programs, including CRO and site selection and relationship- building with investigators and advocacy groups.
• Expertise in clinical trial design, execution, and data interpretation, particularly for Phase 2 and 3
• Demonstrated ability to lead cross-functional teams and drive strategic decision-making.
• Exceptional organizational, analytical, and communication skills, with the ability to translate corporate objectives into actionable clinical plans.
• A proactive, adaptable, and ethical mindset, with a commitment to excellence and collaboration.
• Willingness to travel domestically and internationally (up to 20%) for vendor visits, conferences, regulatory meetings, and advisory boards.

About Maze Therapeutics

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing the power of human genetics to develop novel, small molecule precision medicines for patients living with renal, cardiovascular and related metabolic diseases, including obesity. The company is advancing a pipeline using its Compass platform, which allows it to identify and characterize genetic variants in disease and then link those variants to the biological pathways that drive disease in specific patient groups through a process it refers to as variant functionalization. The company’s pipeline is led by two wholly owned lead programs, MZE829 and MZE782, each of which represents a novel precision medicine-based approach for chronic kidney disease. Maze is based in South San Francisco.

Our People

Maze is comprised of a team of passionate and creative professionals committed to discovering and delivering transformative medicines to patients suffering from both rare and common genetic diseases. We are fostering a culture that encourages vision, initiative and the development of talent. Our supportive work environment inspires creative thinking and freedom of expression, resulting in a stimulating atmosphere where people enjoy coming to work. While we have a passion for advanced science and pride ourselves on excellence in execution, ultimately, everything we do is about patients.

Our Core Values

Further Together – Our path is paved with challenges, but with resilience and a team-first mentality, we’ll achieve our mission.

Impact Obsessed – We embrace the bold, take calculated risks, and learn from our mistakes to improve the lives of others.

Stand True – Our integrity is foundational; it guides us no matter the obstacle.

The expected annual salary range for employees located in the San Francisco Bay Area is $320,000 - $392,000. Additionally, this position is eligible for an annual performance bonus. Maze performs position-based compensation benchmarking to industry market data to ensure we pay competitive wages. Determination of starting salary will depend upon a variety of job-related factors, which may include professional experience, skills, and job location. The expected salary range for this role may be modified in the future.

Maze offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, mental health offerings, equity incentive plan, 401(k) program with employer match and a generous holiday and PTO policy.