About Maxion

Maxion Therapeutics is a biotechnology company developing antibody-based drugs for previously untreatable ion channel- and G protein-coupled receptor (GPCR)-driven diseases, including autoimmune conditions, chronic pain, and cardiovascular disease.

The Company is developing a pipeline of potentially first- and best-in-class therapeutics using its proprietary KnotBody technology to generate potent, selective, and long-acting therapeutics by combining naturally occurring mini-proteins (‘knottins’) with antibodies using state-of-the-art phage and mammalian display technologies.

Maxion was founded in 2020 by highly respected biotech entrepreneurs and scientists Dr John McCafferty, CTO and Dr Aneesh Karatt-Vellatt, CSO. Dr McCafferty previously co-invented antibody phage display, which was the subject of the 2018 Nobel Prize in Chemistry awarded to his co-inventor Sir Gregory Winter. Maxion’s portfolio and growth is being advanced by a team of highly experienced leaders in the discovery and development of antibody-based drugs. The Company is based near Cambridge, UK and is backed by international blue-chip investors. For more information, please visit:

https://www.maxiontherapeutics.com/.

About the Role

We are seeking a highly organised and proactive Senior Scientist II/Principal Scientist
to provide an
in-depth understanding of ion channels and cardiovascular expertise. Reporting to the Director of Discovery Biology, the successful candidate will be responsible for
experimental design, generation and analysis of data and communication of results. The ideal candidate will support the team’s exploration into
the
biology behind our targets, and how these are modulated by our proprietary KnotBody
molecules. We are seeking
a highly experienced ion channel biologist with substantial cardiac electrophysiology knowledge.
Previous experience in drug discovery is desirable but not essential.

Key responsibilities

• Experimental design, performance and analysis of
  experiments to support Maxion’s growing pipeline using manual patch-clamp

• Provide ion channel advice and guidance to the Discovery Biology team members and wider Maxion team

• Provide cardiac biology expertise to support project leaders and Leadership Team in key decisions relating to current and future pipeline programmes

• Mentor junior colleagues to
  strengthen Maxion’s electrophysiology capabilities

Candidate Profile

• PhD or equivalent experience
  with extensive hands-on electrophysiology experience

Essential skills include:

Proven
extensive experience in the following:

• Patch-clamp on all standard mammalian expression systems (HEK/CHO/U2-OS) and iPSC cardiomyocytes (Manual patch-clamp)

• Extensive
  ion channel knowledge,
  ideally in a drug discovery environment, with a
  good
  understanding of cardiac electrophysiology (arrhythmia)

• Attention to detail, commitment to quality and rigorous scientific thinking

• Excellent written and oral communication skills

• Excellent interpersonal skills with the ability to build collaborative working relationships

• Actively contributing to a vibrant and innovative working environment where improvements and new ideas are adopted and freely shared among the teams.

• Desire and ability to work in a fast-paced, quickly changing environment, showing agility/flexibility to meet deadlines and goals and with a can-do attitude

Desirable skills include:

• Extensive experience in cardiac electrophysiology (arrhythmia) in
  an academic and/or
  industrial setting
• Experience in sharp electrode recordings from cardiac slices/cardiac tissue

• Experience in assessment of cardiac action potentials/field potential recordings using multielectrode array systems

What can we offer you?

• A competitive salary, based on experience.

• A comprehensive benefits package including generous pension contribution, Private Life and Medical Insurance, Cycle
  to Work Scheme, participation in the company Share Option Scheme, and more.

• Significant opportunities for career progression within a dynamic company.

• Located in a state-of-the art Science Park with easy access to Cambridge by car, train and bus, and offering on-site gym, cafe, and a vibrant social community.

• Working alongside an innovative team of scientists, including the founders, who are Key Opinion Leaders in the field.

• A supportive work environment with a key focus on fostering collaborative working environment within a friendly team.

To apply for this position, click on the link to upload your CV and covering letter outlining your suitability for this role, including your salary expectations.

This is a permanent position.

Agencies: We are recruiting this role directly with our in-house talent team, so do not need support from agencies. We also have our own preferred suppliers list which is not being reviewed for additions in the next 12 months.