Scientist II/Senior Scientist, Assay Development and Automation

Lila Sciences

Lila Sciences

Cambridge, MA, USA
Posted on May 22, 2025

🚀 About Lila Sciences

Lila Sciences is the world’s first scientific superintelligence platform and autonomous lab for life, chemistry, and materials science. We are pioneering a new age of boundless discovery by building the capabilities to apply AI to every aspect of the scientific method. We are introducing scientific superintelligence to solve humankind's greatest challenges, enabling scientists to bring forth solutions in human health, climate, and sustainability at a pace and scale never experienced before. Learn more about this mission at www.lila.ai

At Lila, we are uniquely cross-functional and collaborative. We are actively reimagining the way teams work together and communicate. Therefore, we seek individuals with an inclusive mindset and a diversity of thought. Our teams thrive in unstructured and creative environments. All voices are heard because we know that experience comes in many forms, skills are transferable, and passion goes a long way.

If this sounds like an environment you’d love to work in, even if you only have some of the experience listed below, please apply.

🌟 Your Impact at Lila


In this role, you will lead the platform development of RNA-based therapeutics and cell engineering, with a focus on building workflows that can be scaled and automated. You will collaborate across cross-functional teams, contribute to project design and execution, and mentor team members to foster innovation and project success.

🛠️ What You'll Be Building

  • RNA Therapeutics Development: Design and optimize high-throughput RNA transfection workflows and develop cell-based assays for RNA constructs (e.g., viability, Alphalisa, flow cytometry, HT imaging).
  • iPSC and Cell Line Engineering: Establish and optimize iPSC differentiation protocols (e.g., hepatic and pancreatic lineages) and generate isogenic cell lines using CRISPR/Cas9 and lentiviral systems.
  • Design of Experiments (Arrayed and Pooled Screens): Lead high-throughput screening campaigns using DOE approaches, validate engineered cell lines, and manage pooled and arrayed screening assays to support payload design strategies.
  • Project Management and Collaboration: Present experimental results and updates during technical meetings with leadership, manage timelines, and foster strategic alignment across internal and client partnerships.
  • Mentorship and Collaboration: Mentor team members, provide technical training, and collaborate across cross-functional teams to support team growth and project outcomes.

🧰 What You’ll Need to Succeed

  • Senior Scientist: PhD with 4+ years, or Master’s with 7+ years of industry experience, or equivalent in Developmental Biology, Biotechnology, Biochemistry, or a related field.
  • Scientist II: PhD with 2+ year, or Master’s with 5+ years of industry experience, or equivalent in Developmental Biology, Biotechnology, Biochemistry, or a related field.
  • Proficiency in gene editing, RNA therapeutics, immune and biochemical assay development.
  • Experience with differentiation of iPSC cells, cell line engineering, stable cell line generation.
  • Familiarity with building and implementing automated workflows for RNA transfection and assay readouts using liquid handling platforms (e.g., Lynx, Echo).
  • Strong communication and presentation skills, with experience in cross-functional collaborations.

✨ Bonus Points For

  • Exposure of in vivo RNA studies
  • Experience with pooled screening workflows
  • Proficiency in Python, Jupyter notebooks, or similar tools for data analysis
  • High-throughput content imaging experience
  • Ability to quickly adapt to new software platforms and strong proficiency in productivity tools like Excel.

🌈 We’re All In

Lila Sciences is committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

🤝 A Note to Agencies

Lila Sciences does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Lila Sciences or its employees is strictly prohibited unless contacted directly by Lila Science’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Lila Sciences, and Lila Sciences will not owe any referral or other fees with respect thereto.