Why join us?

Parabilis Medicines is a highly distinctive young biopharmaceutical company whose intention is to grow over time into the ranks of major therapeutics companies. Our foundational platform of Helicon™ therapeutics are peptides capable of efficient cell entry and modulation of both protein-protein and protein-DNA interactions. Through Helicon therapeutics, Parabilis is poised to revolutionize the medical possibilities for patients by precisely drugging intracellular targets long understood to be significant drivers of disease but never before drugged due to the limitations of existing drug modalities to act within the cell.

An important distinctive element of Parabilis is our lead program FOG-001, the company’s first-in-class TCF-blocking β-catenin inhibitor. This compound is approximately 18 months and ~50 patients into our early development program for patients with advanced solid tumors, most importantly colorectal cancer. There are few products in the ecosystem with the medical and economic potential of FOG-001. Parabilis is fully leveraging the unprecedented potential Helicons present by deploying proprietary, custom-built machine learning and computational methods as part of its discovery and development process. Parabilis Medicines has raised more than $500 million to date from leading life sciences investors. Parabilis Medicines is headquartered in Cambridge, Mass.

What’s the opportunity?

As the AVP/VP of Engineering, you’ll have the opportunity to build and lead our software engineering, data engineering, and technical project/product management functions, and drive high-impact work at the forefront of biotech innovation.

This hands-on role will play a pivotal part in shaping and executing our technology strategy, ensuring the delivery of a scalable, high-quality Helicon™ Platform that powers our scientific and business operations.

The ideal candidate will be an experienced engineering executive leader who thrives at the intersection of technology, data, and product development in a fast-paced, mission-driven environment.

Key Responsibilities

• Leadership & Strategy
• Set and execute the strategic vision for the Engineering organization, including software development, data engineering, infrastructure, and AI enablement.
• Partner closely with stakeholders in Data Science (Computational Chemistry, Computational Biology, and RWD/RWE), Research (Chemistry and Biology), Development (Clinical and CMC), and IT to understand needs and translate them into engineering solutions.
• Promote a culture of innovation, operational excellence, and measurable impact.

• AI Enablement
  • Drive the adoption and integration of AI tools and platforms across Engineering workflows, from automation and analytics to DevOps and application development.
  • Support cross-functional AI adoption efforts in collaboration with Data Science and other departments, ensuring infrastructure, tooling, and process readiness.
  • Stay current on emerging AI technologies and assess their strategic value to the company.

• Software & Data Engineering
• Oversee and contribute to the development and maintenance of internal software tools and data pipelines.
• Ensure high standards for software quality, reliability, security, and compliance.
• Champion and drive best practices in DevOps, CI/CD, and modern data architecture.
• Project & Program Management
• Lead execution of cross-functional initiatives with clear ownership, timelines, and deliverables.
• Manage priorities and resource allocation across multiple projects and teams (both internal and external).
• Establish and improve processes for planning, tracking, and communication.
• Team Building & Development
• Recruit, mentor, and grow a high-performing engineering team.
• Foster a culture of collaboration, innovation, and accountability.
• Promote professional development and succession planning within the organization.

What you’ll need to be successful:

• Computer science degree and 18+ years of experience in software/data engineering, including 7+ years in a senior leadership and people management role.
• Proven track record of building and leading multiple engineering teams simultaneously.
• Deep experience with modern cloud technologies (e.g., AWS), distributed systems, data platforms (e.g., Snowflake, Spark, Airflow), and programming languages (e.g., Python, R)
• Experienced with the latest AI-driven software development tools and processes, e.g., Github Copilot, Claude Code, Open AI Codex.
• Strong project management skills; PMP or Agile/Scrum experience.
• Exceptional communication and cross-functional collaboration skills.
• Experience in life sciences, biotech, or healthcare technology preferred.
• Able to work on-site and attend in-person meetings

Core Values

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Growth-Minded. We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
• In(ter)dependent. We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-In. We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.

As an equal opportunity employer, Parabilis Medicines values diversity and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive | Cambridge, MA 02140 | www.parabilismed.com