Why join us?

Parabilis Medicines is a highly distinctive young biopharmaceutical company whose intention is to grow over time into the ranks of major therapeutics companies. Our foundational platform of Helicon™ therapeutics are peptides capable of efficient cell entry and modulation of both protein-protein and protein-DNA interactions. Through Helicon therapeutics, Parabilis is poised to revolutionize the medical possibilities for patients by precisely drugging intracellular targets long understood to be significant drivers of disease but never before drugged due to the limitations of existing drug modalities to act within the cell.

An important distinctive element of Parabilis is our lead program FOG-001, the company’s first-in-class TCF-blocking β-catenin inhibitor. This compound is approximately 18 months and ~50 patients into our early development program for patients with advanced solid tumors, most importantly colorectal cancer. There are few products in the ecosystem with the medical and economic potential of FOG-001. Parabilis is fully leveraging the unprecedented potential Helicons present by deploying proprietary, custom-built machine learning and computational methods as part of its discovery and development process. Parabilis Medicines has raised more than $500 million to date from leading life sciences investors. Parabilis Medicines is headquartered in Cambridge, Mass.

What’s the opportunity?

This is an exciting opportunity to take a leadership role in bringing a new and potentially transformational drug modality to patients in need. We’re looking for a top scientist and experienced drug development team leader in Biology to drive cell and translational biology for multiple oncology programs against targets previously thought to be undruggable. Strategies for target inhibition include disruption of protein-protein interactions and targeted protein degradation. In this role, you’ll lead one of our cross-functional teams responsible for timely progression of a novel HeliconTM peptide from program nomination through IND filing. Success in the role will require innovation, scientific thought leadership, and excellent communication, program and people management skills.

• Oversee preclinical oncology programs from hit stage through IND with scientific excellence and urgency
• Support translational efforts on clinical programs to maximize probability of clinical success
• Support innovation relating to pipeline build, maximizing multiple platform approaches to enable value creation for the company
• Build and maintain a top-notch team of internal and external scientists and research associates
• Inspire and develop biology team members and foster extensive cross-functional collaboration
• Support evaluation of external opportunities, in-bound and out-bound
• Clearly communicate strategy, execution plans, and results to all levels of the organization

What you’ll need to be successful:

• PhD. in Cancer Biology, Cell or Molecular Biology, Genetics, Biochemistry, or related field with 18+ years post-degree experience with a minimum of 6+ years of program leadership and people management experience
• Demonstrated success in leading oncology drug development programs from inception through IND, and driving multiple, parallel deliverables while executing on biology milestones
• Enthusiastic and innovative mindset with the ability to thrive in a dynamic, fast-pasted, and highly collaborative environment
• Excellent communication, organization, multi-tasking, flexibility, and team skills.
• Able to work on-site and attend in-person meetings

Core Values

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Growth-Minded. We’re inventing a new class of medicines—one applicable to therapeutic targets that have been dreamt about, but always considered impossible to drug. Our work requires us to be curious, humble and adaptable.
• In(ter)dependent. We are fiercely independent as a leader in defying the limitations of current therapeutic modalities, and interdependent as a team as we work collaboratively to shift drug discovery paradigms and provide patients with better treatment options.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-In. We’re All-In on solving some of the hardest scientific challenges and delivering one of the most effective new classes of drugs in history.

As an equal opportunity employer, Parabilis Medicines values diversity and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive | Cambridge, MA 02140 | www.parabilismed.com