Why join us?

Parabilis Medicines (formerly FogPharma) is a biopharmaceutical company pioneering the discovery and development of Helicon™ therapeutics, which are peptides capable of efficient cell entry and modulation of both protein-protein and protein-DNA interactions. Through Helicon therapeutics, Parabilis is poised to revolutionize the medical possibilities for patients by precisely drugging intracellular targets long understood to be significant drivers of disease but never before drugged due to the limitations of existing drug modalities to act within the cell.

FOG-001, the company’s first-in-class TCF-blocking β-catenin inhibitor, is being evaluated in a Phase 1/2 study for patients with advanced solid tumors, including colorectal cancer. Parabilis is fully leveraging the unprecedented potential Helicons present by deploying proprietary, custom-built machine learning and computational methods as part of its discovery and development process. Parabilis Medicines has raised more than $500 million to date from leading life sciences investors. Parabilis is headquartered in Cambridge, Mass.

What’s the opportunity?

We’re looking for a team facing pharmacologist with hands on experience to drive external and internal in vivo studies to support the company’s lead program, FOG-001. In this role, you will be expected to balance study design, execution, analysis, and communication of key findings and next steps to project teams. This role requires a balance of hands-on technical execution and strategic management of CRO relationships critical for execution of FOG-001 preclinical studies. While acting as an individual contributor, this role has exciting opportunities to grow and develop as a drug hunter as you will be a key member of a cross functional team balancing that manages the preclinical, clinical, and commercial interests of FOG-001. As part of this growth, you will learn how to support regulatory filings, support clinical expansion across oncology indications, and how to communicate preclinical findings to senior leaders across the company. You will work within the existing pharmacology team framework and report directly to the Head of Pharmacology. Success in this role will require an industry understanding of pharmacology with a strong scientific background in biology, the ability to manage multiple efforts in parallel, excellent communication skills, and an eagerness to grow as a drug hunter.

Key abilities of this role include:

• Develop, execute, and interpret pre-clinical pharmacology studies
• Management of CROs to execute pharmacology studies
• Integrated knowledge of biology and pharmacology to support key clinical questions
• Cross-functional communicator with abilities to work within a matrix environment to execute studies
• Hands on execution to support internal studies with collaboration of internal pharmacology team members
• Desire to learn and grow as an industry drug hunter
• Inspire and mentor junior pharmacology team members
• Clearly communicate strategy, execution plans, and results to all levels of the organization

What you’ll need to be successful:

• Ph.D. in Biology, Cell or Molecular Biology, Pharmacology or related field with 5+ years post-degree industry pharmacology experience, or MS with 20+ years of relevant industry pharmacology experience.
• Demonstrated success in delivering hands on execution of in vivo studies
• Experience designing, executing and analyzing pre-clinical pharmacology studies from lead optimization through IND is desired, but not required
• Creative and adaptive mindset to thrive in a vertically integrated team environment addressing key questions from preclinical, clinical, and commercial
• Excellent communication, organization, multi-tasking, flexibility, and team skills.
• Able and willing to provide hands on support for pharmacology studies when required
• Able to work on-site and attend in-person meetings

Core Values

Parabilis Medicines is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Growth Mindset & Creative. We are creating a whole new class of medicine requiring creativity to solve challenges as they arise, which we have successfully done since the inception of the company.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• All-in & Execution-oriented. As we begin clinical development and large-scale manufacturing, the team is balancing creativity and nimbleness with relentless, rigorous and flawless execution.
• Interdependent & Humble. We fully appreciate that science and technology and policy are in flux, and we balance deep experience with humility to ask fundamental questions and seek newly available solutions.

As an equal opportunity employer, Parabilis Medicines values diversity and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive | Cambridge, MA 02140 | www.parabilismed.com