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Principal/Sr. Principal Associate Scientist, Cancer Biology

Fog Pharmaceuticals

Fog Pharmaceuticals

Cambridge, MA, USA
Posted on Saturday, June 22, 2024

Why join us?

FogPharma is a biopharmaceutical company pioneering the discovery and development of Helicon™ therapeutics, which are peptides capable of efficient cell entry and modulation of both protein-protein and protein-DNA interactions. Through Helicon therapeutics, FogPharma is poised to revolutionize the medical possibilities for patients by precisely drugging intracellular targets long understood to be significant drivers of disease but never before drugged due to the limitations of existing drug modalities to act within the cell.

FOG-001, the company’s first-in-class TCF-blocking β-catenin inhibitor, is being evaluated in a Phase 1/2 study for patients with advanced solid tumors, including colorectal cancer. FogPharma is fully leveraging the unprecedented potential Helicons present by deploying proprietary, custom-built machine learning and computational methods as part of its discovery and development process. FogPharma has raised more than $500 million to date from leading life sciences investors. FogPharma is headquartered in Cambridge, Mass.

What’s the opportunity?

We are seeking a highly motivated Principal Associate Scientist with experience in cellular and molecular biology techniques for drug discovery. In this role, you will have opportunities to characterize different cellular activities for our novel HeliconTM peptides and help us develop this new drug modality for cancer and other diseases with unmet medical needs. Ideal candidates will be energetic and passionate, with a breadth of cell-based assay and molecular biology experience, along with a demonstrated ability to drive and deliver results, and an interest in working in a dynamic, fast-paced environment. As part of this role, you will:

  • Develop and perform cellular and molecular biology assays to screen and evaluate drug activity and mechanism of action
  • Contribute to transition of lead helicons to development candidate status and IND-enabling experimentation
  • Accurately record, analyze, and present data to team and company leadership
  • Collaborate across functional teams to efficiently identify drug candidates and move them to the clinic
  • Contribute to, and be a part of, an exciting and dedicated group of people pushing the forefront of oncology therapeutics

What you’ll need to be successful:

  • BS. or M.S. in cancer biology or related field with 10+ years of relevant industry experience
  • Hands-on experience developing and performing biochemical and cell-based assays such as HTRF/AlphaLISA/MSD/NanoBRET is required
  • Hands-on experience in performing high-throughput screening using cellular readouts is required
  • Hands-on experience with CRISPR and/or RNAi to evaluate gene function is required
  • Hands-on experience with immunofluorescence and confocal microscopy is preferred
  • Proficiency in a broad range of biochemical, molecular and cellular techniques including (but not limited to): mammalian cell culture, western blotting, qPCR, transfection, flow cytometry etc.
  • Experience in managing relationships with collaborators or CROs is preferred
  • Experience working with ADCs and/or RLTs is highly desired
  • Experience working with cell surface receptors and internalization is highly desirable
  • Innovative, creative, inquisitive, motivated researcher with strong problem-solving skills
  • Excellent written and oral communication skills with a proven track record of publications
  • Able to work on-site and attend in-person meetings

As an equal opportunity employer, Fog values diversity and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

Core Values

FogPharma is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

  • Creative. We are creating a whole new class of medicine requiring creativity to solve challenges as they arise, which we have successfully done since the inception of the company.
  • Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
  • Execution-oriented. As we begin clinical development and large-scale manufacturing, the team is balancing creativity and nimbleness with relentless, rigorous and flawless execution.
  • Humble. We fully appreciate that science and technology and policy are in flux, and we balance deep experience with humility to ask fundamental questions and seek newly available solutions.

As an equal opportunity employer, Fog values diversity and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive | Cambridge, MA 02140 | www.fogpharma.com