Why join us?

FogPharma is a biopharmaceutical company pioneering the discovery and development of Helicon™ therapeutics, which are peptides capable of efficient cell entry and modulation of both protein-protein and protein-DNA interactions. Through Helicon therapeutics, FogPharma is poised to revolutionize the medical possibilities for patients by precisely drugging intracellular targets long understood to be significant drivers of disease but never before drugged due to the limitations of existing drug modalities to act within the cell.

FOG-001, the company’s first-in-class TCF-blocking β-catenin inhibitor, is being evaluated in a Phase 1/2 study for patients with advanced solid tumors, including colorectal cancer. FogPharma is fully leveraging the unprecedented potential Helicons present by deploying proprietary, custom-built machine learning and computational methods as part of its discovery and development process. FogPharma has raised more than $500 million to date from leading life sciences investors. FogPharma is headquartered in Cambridge, Mass.

What’s the opportunity?

We seek a highly talented and motivated Principal Data Engineer to support the discovery and development platform for Helicon^TM peptide drugs. Reporting to the Senior Director of Data Engineering, the candidate will work collaboratively with biologists, chemists, and data scientists, leveraging skills in data engineering to enable data capture, integration, reporting, and computational insight delivery from our computer systems to support hypothesis generation, data insights, and data science for advancing Fog preclinical drug discovery.

You’ll be part of a data science team that is a central pillar of FogPharma’s innovative discovery and development platform and pipelines targeting “undruggable” protein targets involved in deadly disease of major therapeutic interest to patients. Our data science team is an integrated team ranging from computational biology, bioinformatics, computational drug discovery, research informatics and data engineering. We work at the interface of chemistry, biology, clinical and computational sciences, and are responsible for all aspects of data science from building the discovery pipeline to supporting and developing our discovery and clinical platform.

• Work with project stakeholders to establish data management and analytics needs across R&D functions.
• Collaborate with cross-functional teams, including scientists, data scientists, software developers, and external partners, to gather user stories, define, and prioritize the product backlog for platforms that support the overall R&D strategy and objectives.
• Identify, investigate, and develop solutions for data capture, reporting, and issue resolution.
• Identify, investigate, and develop solutions for computational insight delivery (machine learning models and simulation).
• Create and maintain documentation on dataflows, system usage, and system configuration.
• Coordinate the training and support of end-users on system usage and best practices.

What you’ll need to be successful:

• Ten years of relevant experience in life sciences and computer science, engineering, or a related field.
• Experience with scientific data management, compound registration, sample inventory, instrument data capture, assay results, and electronic laboratory notebooks, specifically on Dotmatics.
• Experience with machine learning model and simulation output delivery

• Experience with programming and scripting languages like Python, SQL
• Advanced experience working in agile methodology (Scrum/Kanban).
• Knowledge of the software development life cycle
• Experience as a product owner.
• Proven experience working closely with scientific stakeholders to understand their informatics needs, and subsequently defining complex system requirements, scope, objectives, and key results in the context of larger organizational goals.
• Able to work on-site and attend in-person meetings.

Core Values

FogPharma is a team of passionate pioneers who are trailblazing the future of precision medicine with the aim of making a meaningful difference in the lives of patients. The company is committed to promoting an inspiring and flourishing working environment for all employees across the business, in all departments, and driving innovation for patient benefit.

• Creative. We are creating a whole new class of medicine requiring creativity to solve challenges as they arise, which we have successfully done since the inception of the company.
• Patient-focused. We are deeply focused on patient outcomes, and all energy in the company is focused on science as it translates to patient impact.
• Execution-oriented. As we begin clinical development and large-scale manufacturing, the team is balancing creativity and nimbleness with relentless, rigorous and flawless execution.
• Humble. We fully appreciate that science and technology and policy are in flux, and we balance deep experience with humility to ask fundamental questions and seek newly available solutions.

As an equal opportunity employer, Fog values diversity and welcomes applicants of all backgrounds and experiences. All qualified applicants will receive consideration for employment without discrimination on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability, or any other factors prohibited by law.

30 Acorn Park Drive | Cambridge, MA 02140 | www.fogpharma.com