Senior Scientist II, Cancer Biology

CHARM Therapeutics is a biotech company focused on delivering transformational medicines that will address difficult-to-drug targets in key oncogenic pathways.

CHARM has developed the first highly accurate, high throughput protein-ligand co-folding algorithm (DragonFold), driven by end-to-end 3D deep learning. Our platform enables the rapid generation of highly differentiated clinical candidates, and our ambition is to revolutionise drug discovery.

CHARM Therapeutics is establishing a state-of-the-art R&D facility in Cambridge, UK. We are currently seeking an experienced Biologist with a passion for scientific innovation to join the Cancer Biology group at CHARM Therapeutics. You will help increase the biological understanding of programs as well as developing the strategy required to help propel our programs forward. Your role will be comprised of:

• Identifying and building novel assays to understand compound mechanism-of-action
• Developing novel and state of the art multi-cell assay formats
• Novel target/technology identification
• Working in a matrixed team
• Communicating with team members and leadership teams

The successful candidate will join a multidisciplinary, highly collaborative discovery team to invent novel medicines and drive them towards the clinic.

Role Requirements

You are a highly motivated and independent individual with excellent communication and interpersonal skills who is effective at working in a collaborative and diverse environment.

You have a PhD degree in one of the following fields – biotechnology, biochemistry, biology, pharmacology or a related field and have:

• A background in oncology and ability to understand the biology around novel targets and pathways to develop scientific hypotheses.
• Minimum 2 years’ experience in biotech/pharma
• Experience in running routine assays for development of a therapeutic agent.
• Proficient at a range of high-throughput plate-based assay technologies including but not limited to fluorescence, luminescence, TR-FRET, imaging and ELISAs with both endpoint and kinetic readouts.
• Experience with culturing primary cells and cancerous cells
• Know-how in design and evaluation of experimental set up, and ability to work independently.
• Excellent ability to analyse, write up and communicate experimental results.
• Able to work in a highly flexible environment.

What We Offer

• Private medical insurance, including dental cover.
• Competitive pension scheme
• Gym membership
• Weekly team lunch
• Office fruits & snacks
• Regular socials