Senior Data Engineer
CHARM Therapeutics
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CHARM Therapeutics is a biotech focused on delivering transformational medicines that will address difficult-to-drug targets in key oncogenic pathways. CHARM has developed the first highly accurate, high throughput protein-ligand co-folding algorithm (DragonFold), driven by end-to-end 3D deep learning. Our platform enables the rapid generation of highly differentiated clinical candidates, our ambition is to revolutionise drug discovery.
CHARM Therapeutics has established a state-of-the-art R&D facility in Cambridge, UK. We are seeking a Senior Data Engineer with a passion for innovation. This role will be instrumental in enabling our oncology-focussed drug discovery pipeline through establishing and improving our data platform. The successful candidate must have excellent interpersonal and cross-functional collaboration skills, and will join a multidisciplinary, highly collaborative team of scientists and engineers to invent novel medicines.
Responsibilities
- Supporting drug design cycles across multiple programs by ensuring data transformations are operating at all times
- Architect and build a system for ingesting and organising internal and external data, including affinity data and structural data, enabling a drug discovery design cycles
- Liaising with program teams to optimise data usage in drug discovery, including chemistry and biology assay data, as necessary to support project decisions
- Coordinating external data curation
- Continually looking for opportunities to improve the accessibility of project data across the portfolio
Requirements
- 3+ years of experience in a biotechnology environment
- Strong data engineering skills
- Domain knowledge of key data resources to support drug discovery
- Familiarity with ChEMBL, GoSTAR or similar databases
- SQL for relational database querying
- Demonstrable ETL (Extract, Transform, Load) workflow experience, standardisation and data wrangling skills in Python
- Strong team player with an inclusive mindset
- Proven track record of setting up and maintaining data analytics and visualisation systems
- Knowledge of collaborative data science environments (e.g. Jupyter Notebook)
Highly desirable skills
- MSc or higher degree in drug discovery, biochemistry, pharmacology, or medicinal chemistry
- Knowledge of ontologies
- Hands on experience of manipulating bioactivity data
- Familiarity with Electronic Lab Notebooks
- Familiarity with Linux and command line tools
- Knowledge of TIBCO Spotfire
This job is no longer accepting applications
See open jobs at CHARM Therapeutics.See open jobs similar to "Senior Data Engineer" General Catalyst.