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Senior Scientist, Biological and Translational Sciences (Larrieu Lab)

Altos Labs

Altos Labs

Cambridge, UK
Posted on Saturday, June 29, 2024

Our Mission

Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life.

For more information, see our website at

Our Value

Our Single Altos Value: Everyone Owns Achieving Our Inspiring Mission.

Diversity at Altos

We believe that diverse perspectives are foundational to scientific innovation and inquiry.

We are building a company where exceptional scientists and industry leaders from around the world work side by side to advance a shared mission.

Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives.

At Altos, we are all accountable for sustaining a diverse and inclusive environment.

What You Will Contribute To Altos

An exciting opportunity is available for a Senior Scientist to join the Larrieu group at Altos Labs, Cambridge Institute of Science (Cambridge, UK). We are seeking a very highly motivated, creative, and collaborative individual with previous experience in target identification/ validation and drug discovery in a biotech setting, who is passionate and dedicated about employing their expertise to unravel the deep biology of cell health and resilience. This includes the elucidation of age-related changes in nuclear envelope biology, and potential interventions to reverse, halt or mitigate the effects of ageing on nuclear envelope dysfunction.

The Larrieu Lab

The Larrieu Lab has developed pioneering approaches based on the principle of synthetic rescue and relying on cutting-edge genetic screening approaches, to discover novel targets and cellular pathways that can reverse age-associated dysfunction of the nuclear envelope. Using models of accelerated ageing, her findings have helped unravelling new mechanisms underlying nuclear envelope dysfunction, improved our understanding of premature and physiological ageing and could contribute to the development of novel therapies. At Altos, the lab is interested in bringing new understanding of cellular resistance and resilience to nuclear envelope dysfunction in ageing, exploring both fundamental questions and translational opportunities.


  • Study the mechanistic basis of age-associated nuclear envelope dysfunction.
  • Elucidate processes that contribute to the age-related erosion of cell/tissue resilience.
  • Engage in ground-breaking and innovative science and in Altos scientific activities.
  • Develop project-specific experimental strategies, techniques, and procedures including new assays and pipelines to support translational projects.
  • Lead, design and execute experiments for identification and validation of targets with therapeutic potential
  • Develop and implement biochemical and cellular assays to support screening and characterization of potential candidate therapies
  • Collaborate widely across Altos to multiply efforts to gain insight into the centrality of the nuclear envelope in ageing and identify potential new therapeutic avenues
  • Collaborate with multidisciplinary teams including chemists, pharmacologists, and bioinformaticians to advance drug discovery projects.
  • Present data to a variety of audiences including senior executives through entry-level employees.
  • Carry out research projects in collaboration with the principal investigator, members of the group and other labs within Altos.

Who You Are

Minimum Qualifications

  • PhD in life sciences
  • Relevant biotech experience in target identification/ validation in drug discovery and experience with leading research projects.
  • Molecular and cell biology with experience in assay development and validation to support pre-clinical studies.
  • Extensive experience in mammalian cell culture (including primary cells).
  • Knowledge and strong interest in studying age-related molecular changes.
  • A strong sense of collective ownership of projects within the group and Altos.
  • Critical, visionary, and creative thinking with an ability to formulate scientific questions, design strategies, and implement plans effectively.
  • Highly adaptable with an ability to work both independently and with others.
  • A demonstrated high productivity
  • Strong organizational skills to manage multiple tasks simultaneously, prioritize workloads, and meet deadlines.
  • Ensures accuracy and precision in experimental procedures, data recording, and documentation.
  • Problem-solving skills to identify potential issues, test, and develop innovative solutions.
  • Excellent writing and communication skills

Preferred Qualifications

  • Mastery of advanced molecular biology techniques.
  • Bioinformatics skills would be preferred.

The salary range for Cambridge, UK:

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Exact compensation may vary based on skills, experience, and location.

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- This Privacy Notice is not a contract, express or implied and it does not set terms or conditions of employment.

What We Want You To Know

We are a culture of collaboration and scientific freedom, and we believe in the values of diversity, inclusion and belonging to inspire innovation.

Altos Labs provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Altos currently requires all employees to be fully vaccinated against COVID-19, subject to legally required exemptions (e.g., due to a medical condition or sincerely-held religious belief).

Thank you for your interest in Altos Labs where we strive for a culture of scientific freedom, learning, and belonging.

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