What You Will Contribute To Altos

An exciting opportunity is available for a Senior Scientist to join the Larrieu group at Altos Labs, Cambridge Institute of Science (Cambridge, UK). We are seeking a very highly motivated, creative, and collaborative individual with previous experience in target identification/ validation and drug discovery in a biotech setting, who is passionate and dedicated about employing their expertise to unravel the deep biology of cell health and resilience. This includes the elucidation of age-related changes in nuclear envelope biology, and potential interventions to reverse, halt or mitigate the effects of ageing on nuclear envelope dysfunction.

The Larrieu Lab

The Larrieu Lab has developed pioneering approaches based on the principle of synthetic rescue and relying on cutting-edge genetic screening approaches, to discover novel targets and cellular pathways that can reverse age-associated dysfunction of the nuclear envelope. Using models of accelerated ageing, her findings have helped unravelling new mechanisms underlying nuclear envelope dysfunction, improved our understanding of premature and physiological ageing and could contribute to the development of novel therapies. At Altos, the lab is interested in bringing new understanding of cellular resistance and resilience to nuclear envelope dysfunction in ageing, exploring both fundamental questions and translational opportunities.

Responsibilities

• Study the mechanistic basis of age-associated nuclear envelope dysfunction.
• Elucidate processes that contribute to the age-related erosion of cell/tissue resilience.
• Engage in ground-breaking and innovative science and in Altos scientific activities.
• Develop project-specific experimental strategies, techniques, and procedures including new assays and pipelines to support translational projects.
• Lead, design and execute experiments for identification and validation of targets with therapeutic potential
• Develop and implement biochemical and cellular assays to support screening and characterization of potential candidate therapies
• Collaborate widely across Altos to multiply efforts to gain insight into the centrality of the nuclear envelope in ageing and identify potential new therapeutic avenues
• Collaborate with multidisciplinary teams including chemists, pharmacologists, and bioinformaticians to advance drug discovery projects.
• Present data to a variety of audiences including senior executives through entry-level employees.
• Carry out research projects in collaboration with the principal investigator, members of the group and other labs within Altos.

Who You Are

Minimum Qualifications

• PhD in life sciences
• Relevant biotech experience in target identification/ validation in drug discovery and experience with leading research projects.
• Molecular and cell biology with experience in assay development and validation to support pre-clinical studies.
• Extensive experience in mammalian cell culture (including primary cells).
• Knowledge and strong interest in studying age-related molecular changes.
• A strong sense of collective ownership of projects within the group and Altos.
• Critical, visionary, and creative thinking with an ability to formulate scientific questions, design strategies, and implement plans effectively.
• Highly adaptable with an ability to work both independently and with others.
• A demonstrated high productivity
• Strong organizational skills to manage multiple tasks simultaneously, prioritize workloads, and meet deadlines.
• Ensures accuracy and precision in experimental procedures, data recording, and documentation.
• Problem-solving skills to identify potential issues, test, and develop innovative solutions.
• Excellent writing and communication skills

Preferred Qualifications

• Mastery of advanced molecular biology techniques.
• Bioinformatics skills would be preferred.

The salary range for Cambridge, UK:

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Exact compensation may vary based on skills, experience, and location.

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