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Senior Scientist, Purification Process Development and Manufacturing

Altos Labs

Altos Labs

San Francisco, CA, USA
Posted on Saturday, May 11, 2024

Our Mission

Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life.

For more information, see our website at

Our Value

Our Single Altos Value: Everyone Owns Achieving Our Inspiring Mission.

Diversity at Altos

We believe that diverse perspectives are foundational to scientific innovation and inquiry.

We are building a company where exceptional scientists and industry leaders from around the world work side by side to advance a shared mission.

Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives.

At Altos, we are all accountable for sustaining a diverse and inclusive environment.

What You Will Contribute To Altos

The Altos Institute of Medicine will capture knowledge generated about cell health and programming and develop transformative medicines. We are seeking a highly experienced Senior Scientist in purification process development and manufacturing to join the Technical Operations team within the Institute of Medicine. The candidate will work in a highly dynamic and cross-functional environment. The successful candidate will lead downstream process development and support outsourced GMP manufacturing for Altos programs. Modalities include AAV gene therapy, mRNA and protein therapeutics.


  • Lead purification process development for AAV gene therapy, mRNA and protein therapeutics.
  • Establish internal downstream capabilities, design and execute on studies for purification process improvement and troubleshooting, and produce materials to supply non-clinical studies.
  • Manage and collaborate with manufacturing organizations to optimize/ improve downstream purification processes, scale up, and establish in-process control strategies.
  • Support GMP manufacturing at CDMOs, review GMP documents, troubleshoot technical issues, support deviation investigation, and lead risk assessment.
  • Author, review, and/or approve development reports, regulatory filing, or other controlled documents.
  • Collaborate cross-functionally with upstream, analytical development, quality control, QA, Institutes of Science, development sciences, clinical, regulatory, program management, legal and finance.
  • Recruit and provide direction and leadership to development associates as the team expands.
  • Stay abreast of industry trends, emerging technologies, and regulatory guidelines to contribute to the continuous improvement of processes and compliances.
  • Actively contribute to a team culture that promotes continuous improvement, ownership, professional growth, and inclusion.

Who You Are


  • Ph.D. in chemical engineering, biochemical engineering, biotechnology, or related field of biological sciences. Minimum 8+ years of purification process development experience in biotech/pharmaceutical industry.
  • Proven expertise in downstream process development for AAV vectors. Experiences in multiple modalities--AAV gene therapy, protein, and mRNA therapeutics, is a plus.
  • Hands-on experiences with chromatography, filtration, TFF, and other downstream processing techniques.
  • Strong problem-solving skills with ability to interpret complex data sets.
  • Knowledge of regulatory requirements and quality standards related to biopharmaceutical manufacturing.
  • Experienced in achieving CMC deliverables through outsourcing to Contract Manufacturing Organizations.
  • Ability to work in a dynamic environment, with a willingness to learn new skills and adapt to shifting priorities and tasks.
  • Excellent communication skills. Proven capability to collaborate effectively in a diverse, global, cross-functional structure and commit to diversity, equity, and belonging.

The salary range for Redwood City, CA:

  • Senior Scientist I: $169,000 - $234,000
  • Senior Scientist II: $195,000 - $261,600

Exact compensation may vary based on skills, experience, and location.

For UK applicants, before submitting your application:

- Please click here to read the Altos Labs EU and UK Applicant Privacy Notice (
- This Privacy Notice is not a contract, express or implied and it does not set terms or conditions of employment.

What We Want You To Know

We are a culture of collaboration and scientific freedom, and we believe in the values of diversity, inclusion and belonging to inspire innovation.

Altos Labs provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Altos currently requires all employees to be fully vaccinated against COVID-19, subject to legally required exemptions (e.g., due to a medical condition or sincerely-held religious belief).

Thank you for your interest in Altos Labs where we strive for a culture of scientific freedom, learning, and belonging.

Note: Altos Labs will not ask you to download a messaging app for an interview or outlay your own money to get started as an employee. If this sounds like your interaction with people claiming to be with Altos, it is not legitimate and has nothing to do with Altos. Learn more about a common job scam at