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Senior Director / Executive Director, Safety Assessment

Altos Labs

Altos Labs

Sales & Business Development
San Francisco, CA, USA
Posted on Friday, February 2, 2024

Our Mission

Our mission is to restore cell health and resilience through cell rejuvenation to reverse disease, injury, and the disabilities that can occur throughout life.

For more information, see our website at

Our Value

Our Single Altos Value: Everyone Owns Achieving Our Inspiring Mission.

Diversity at Altos

We believe that diverse perspectives are foundational to scientific innovation and inquiry.

We are building a company where exceptional scientists and industry leaders from around the world work side by side to advance a shared mission.

Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives.

At Altos, we are all accountable for sustaining a diverse and inclusive environment.

What You Will Contribute To Altos

An exciting opportunity is available for a talented Director / Senior Director to join the Institute of Medicine (IOM) Development Sciences team at Altos Labs.

We are seeking very highly motivated, creative, and collaborative individuals who are passionate and dedicated to employing their expertise to restore cell health and resilience and reverse disease. This position will be part of a multidisciplinary team within the IOM to develop novel therapeutic projects and pipelines at Altos. The candidate will work in a highly dynamic and cross-functional environment that requires collaboration with the Institutes of Science and may span multiple therapeutic areas and therapeutic modalities. The successful candidate will have strong scientific training, be adept with working with traditional and non-traditional therapeutic modalities, and a demonstrated track record of leading Toxicology groups in the biotechnology or pharmaceutical industry.


  • Develop and implement Toxicology strategies and build infrastructure to support discovery and development programs using internal resources and CROs
  • Recruit scientists and build a team to support Toxicology strategy across the three Altos sites (Toxicology, Pathology, Nonclinical Operations), to ensure delivery of high quality data packages in support of target validation through to regulatory filings
  • Conduct target safety assessments for early therapeutic targets, and work closely with laboratories in the Institutes of Science to understand and derisk the safety of targets early on
  • Plan and execute in vitro safety screens to lead optimize small molecules, ASOs and gene therapy vectors
  • Work closely with CROs to coordinate and manage external toxicology studies
  • Represent Toxicology in multifunctional discovery and early development project teams
  • Effective cross-functional collaboration, especially with Institutes of Science, In Vivo Pharmacology and DMPK, in the optimization of drug leads and candidates
  • Contribute to the cross-functional review of regulatory documents and author and review Toxicology sections for relevant regulatory documents
  • Recommend, initiate, lead and champion new innovations to ensure relevant cutting-edge science is applied to project related issues
  • Create and foster strong partnerships with groups at the Institutes of Science
  • Contributes to a team culture that promotes continuous improvement, ownership, professional growth, and inclusion

Who You Are


  • PhD in Toxicology, Pharmacology or related sciences (or DVM) and a minimum of 10-15+ years of industry experience in Toxicology
  • Deep expertise in Discovery Toxicology, with demonstrated ability to work effectively with early research teams
  • Strong scientific aptitude and ability to implement investigative strategies to elucidate mechanisms of toxicity
  • Demonstrated ability to build, manage and lead groups responsible for supporting Toxicology deliverables in a team setting
  • Demonstrated understanding and established level of expertise employing preclinical models
  • Experience with small molecule safety lead optimization and investigative toxicology efforts
  • Strong knowledge and agility in study design and data interpretation and in the integration of Toxicology studies in the drug progression paradigm, as well as in the incorporation of safety endpoints in pharmacology studies
  • 3Rs-centered, welfare-oriented approach to animal-based research
  • A critical thinker with the ability to analyze possibilities and solutions and make pragmatic trade-off
  • Clear and influential communicator: exceptional influencing skills that demonstrate strong thought partnership and create effective relationships with internal and external groups and individuals

Preferred Qualifications

  • Experience working across diverse therapeutic modalities, including small molecules, biotherapeutics, nucleic acid therapeutics, and gene therapy is highly desirable
  • Project team leadership experience in the discovery space is highly desirable

The salary range for Redwood City, CA:

  • Director: $265,200 - $358,800
  • Senior Director: $324,700 - $439,300

Exact compensation may vary based on skills, experience, and location.

For UK applicants, before submitting your application:

- Please click here to read the Altos Labs EU and UK Applicant Privacy Notice (
- This Privacy Notice is not a contract, express or implied and it does not set terms or conditions of employment.



What We Want You To Know

We are a culture of collaboration and scientific freedom, and we believe in the values of diversity, inclusion and belonging to inspire innovation.

Altos Labs provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Altos currently requires all employees to be fully vaccinated against COVID-19, subject to legally required exemptions (e.g., due to a medical condition or sincerely-held religious belief).

Thank you for your interest in Altos Labs where we strive for a culture of scientific freedom, learning, and belonging.

Note: Altos Labs will not ask you to download a messaging app for an interview or outlay your own money to get started as an employee. If this sounds like your interaction with people claiming to be with Altos, it is not legitimate and has nothing to do with Altos. Learn more about a common job scam at