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Senior Director, Oligonucleotide Process Development and Manufacturing

Altos Labs

Altos Labs

Sales & Business Development
San Francisco, CA, USA
Posted on Friday, June 9, 2023

Our Mission

To restore cell health and resilience through cellular rejuvenation programming to reverse disease, injury, and the disabilities that can occur throughout life.

Diversity at Altos

We believe that diverse perspectives are foundational to scientific innovation and inquiry.

We are building a company where exceptional scientists and industry leaders from around the world work side by side to advance a shared mission.

Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives.

At Altos, we are all accountable for sustaining a diverse and inclusive environment.

What You Will Contribute To Altos

The Altos Institute of Medicine will capture knowledge generated about cell health and programming and develop transformative medicines. We are seeking a highly experienced oligonucleotide CMC leader to join the Technical Operations team within the Institute of Medicine. The candidate will work in a highly dynamic and cross-functional environment that will have close collaboration with the Institutes of Science and span multiple therapeutic areas. The successful candidate will lead the CMC development of Oligonucleotide products including process development and manufacturing.


  • Lead oligonucleotide process development and manufacturing including ASOs and SiRNAs
  • Build a high performing team and build internal and external oligonucleotide capabilities
  • Serve as CMC lead on program core teams and manage Contract Manufacturing Organizations to deliver oligonucleotide products for tox studies and clinical trials
  • Ensure material specifications, process capabilities, yields, and manufacturing and scale-up strategies are sound for future Altos products
  • Lead teams on troubleshooting and data analysis to solve technical problems in manufacturing to ensure manufacturing output and product quality
  • Author regulatory filings, participate in regulatory agency meetings and address questions
  • May lead small molecule CMC development depending on experience
  • Create and foster strong partnerships with Institutes of Science, development sciences, clinical, regulatory, program management, business development, legal and finance
  • As a member of the Tech Ops leadership team, build the Tech Ops organization, processes, systems and infrastructure
  • Actively contribute to a team culture that promotes continuous improvement, ownership, professional growth, and incl

Who You Are


  • Ph.D. in chemistry, biological sciences or engineering and at least 15+ years of relevant industry experience
  • Expertise in oligonucleotide process and analytical development including solid phase synthesis
  • Highly experienced in achieving CMC deliverables through outsourcing to Contract Manufacturing Organizations
  • Experienced in leading CMC teams
  • Small molecule process development experience desirable
  • A critical thinker with the ability to analyze possibilities and solutions and make pragmatic trade-offs, as well as a big-picture innovator who can identify opportunities and is comfortable with ambiguity
  • Strong communication and collaboration skills. Clear and influential communicator. Build effective relationships and partnerships with internal and external stakeholders
  • Proven capability to lead, motivate and inspire in a diverse, global, cross-functional structure and commit to diversity, equity, and belonging.

The salary for the Senior Director level is: $289,850 - $392,150.


What We Want You To Know

We are a culture of collaboration and scientific freedom, and we believe in the values of diversity, inclusion and belonging to inspire innovation.

Altos Labs provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.

This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Altos currently requires all employees to be fully vaccinated against COVID-19, subject to legally required exemptions (e.g., due to a medical condition or sincerely-held religious belief).

Thank you for your interest in Altos Labs where we strive for a culture of scientific freedom, learning, and belonging.

Note: Altos Labs will not ask you to download a messaging app for an interview or outlay your own money to get started as an employee. If this sounds like your interaction with people claiming to be with Altos, it is not legitimate and has nothing to do with Altos. Learn more about a common job scam at